Τηλέφωνο:  (+30) 2310 999540 

Email:  abakopoulou@dent.auth.gr 

Σπουδές – Τίτλοι:  

2000: DDS, National & Kapodistrian University of Athens, Grade: Excellent (8.75).
2001-2004: Postgraduate Program in Prosthodontics, Department of Fixed Prosthesis and Implant
Prosthodontics, School of Dentistry, Aristotle University of Thessaloniki
2004-2007: PhD, Department of Fixed Prosthesis and Implant Prosthodontics, School of Dentistry,
Aristotle University of Thessaloniki

Ακαδημαϊκή σταδιοδρομία:  

2015-today: Assistant Professor Department of Fixed Prosthesis and Implant Prosthodontics, School
of Dentistry, Aristotle University of Thessaloniki
2011-2015: Lecturer, Department of Fixed Prosthesis and Implant Prosthodontics, School of Dentistry,
Aristotle University of Thessaloniki
2009-today Visiting Research Fellow, Department of Conservative Dentistry, Periodontology and
Preventive Dentistry, Medical University of Hannover, Germany
2007-2011 (after completing PhD Studies): Clinical Instructor, Department of Fixed Prosthesis and
Implant Prosthodontics, School of Dentistry, Aristotle University of Thessaloniki-AUTH

Τιμητικές διακρίσεις:  

 1st Senior Robert Frank Award 2009-Basic Science at the 44th CED/IADR Annual Meeting in
Munich, 9-12 September 2009
 Invitation to participate with a research presentation, entitled: “Osteo/odontogenic potential of
mesenchymal stem cells of human developing teeth” at the International Hatton Competition, held at
the 88th IADR, General Session, 14-14 July, Barcelona, Spain
 First Place for “Outstanding Poster Presentation” at the 12th meeting of the International College
of Prosthodontists, in Fukuoka, Japan (5-9 September 2007)
 First Young Prosthodontist award at the 11th meeting of the International College of
Prosthodontists, in Crete, Greece (25-28 May 2005)
 1st place with honors and award for the best poster presentation, entitled “Protocols for immediate
implant loading in the mandibular posterior jaw” by Papathanasiou Ι, Bakopoulou A, Koidis P.
Annual Congress of the Stomatological Society of Northern Greece, Thessaloniki, 30th March-1st
April 2012
 Awarded by the Hellenic Academy of Science for 1st place in graduation from the School of
Dentistry of the National & Kapodistrian University of Athens (October 2002)
 Colgate-Palmolive award and grant for the 1st place in graduation rank from the School of
Dentistry, National and Kapodistrian University of Athens (2001)
 CORREGA award for obtaining the 1st place at the final undergraduate examination in
Removable Prosthodontics (2000)
 Awarded by the Department of Anatomy, School of Medicine, University of Athens for taking the
1st place (grade 10 in a 10 grading scale) in the Anatomy examinations (1996)
 Awarded by the Greek State Scholarship Foundation for achieving first place (based on each
year’s grades) in every academic year of undergraduate studies (1995-96, 1996-97, 1997-98, 1998-99,
1999-2000)
Scholarships
 05/2009-11-2009 and 07/2012-10/2012: Scholarships from the German Academic Exchange
Service (Deutsche Akademische Austauschdienst-DAAD) for conducting research in Germany at
the Department of Conservative Dentistry, Periodontology and Preventive Dentistry, Medical
University of Hannover -MHH (Director: Prof. Dr. W. Geurtsen), as analytically described in section
“Research Activity” pp. 10-13.
 Scholarship through the program of Academic Exchanges LLP/ERASMUS for acquiring
specialized training in advanced cell culture and molecular biology techniques, time period: 20-
24/2/2012
 2005-2007: Scholarship from the “Alexander S. Onassis” Public Benefit Foundation:
Scholarship for postgraduate (PhD) studies
 1995-2000: Scholarships and first place awards from the State Scholarship Foundation
(SSF/IKY) for each year of undergraduate studies

Μέλος Επιστημονικών Εταιρειών:  

 International Association for Dental Research
 Hellenic Society of Bioaterials
 Stomatological Society of Northern Greece
 Society of Gene therapy
 European Cell Death Organisation (ECDO) (2004-2005)

Οργανωτική και Διοικητική δραστηριότητα:  

 Member of the General Assembly of the School of Dentistry (academic years 2011-2012 and 2013-
2014)
 Member of the Committee of the tender Nr. 312/2012 for the provision of consumable dental
materials of the School of Dentistry (2012)
 Member of the Committee for the provision of supplies, services, instruments, materials and
consumables for the needs of the Department of Fixed Prosthesis and Implant Prosthodontics, School
of Dentistry, -AUTH (year 2012-2013)
 Member of the Committee for the provision of consumables, dental materials, instruments and
units, as well as for the assessment of proper function/use of these facilities in the School of Dentistry
(financial year 2013)
 Member of the Committee for the approval of supplies and instruments and for the assessment of
proper function of the Department of Fixed Prosthesis and Implant Prosthodontics, School of
Dentistry, -AUTH (financial year 2013)
 Member of the Committee for conducting a low-value procurement procedure for the supply of
consumable dental materials in the School of Dentistry (2013)
 Member of the Committee of the Historical Archive of the School of Dentistry (General Assembly
Decision Nr. 297/15.10.2013)
 Member of the Committee for the approval of materials, instruments and consumables of the
Department of Fixed Prosthesis and Implant Prosthodontics, School of Dentistry, -AUTH (financial
year 2011)
 Representative of the Department of Fixed Prosthesis and Implant Prosthodontics, School of
Dentistry, -AUTH in the exams for the recognition of DDS Degrees of people studying outside the EU
(DOATAP, December 2012)

Ερευνητική δραστηριότητα – Προγράμματα:  

After completing my PhD studies, I conducted post-doctoral research in collaboration with specialized
research groups/laboratories in Greece and Germany (ongoing until today). In this context the
following research protocols have been completed or are currently running:
 Research Protocol
“Investigation of gene expression profiles of human pulp and gingival fibroblasts after exposure to
different resin-based dental restorative materials or their compounds”
Time period: 2007-2009
This was conducted in collaboration with the Department of Pharmacology, School of
Pharmaceutical Sciences, Aristotle University of Thessaloniki (Head: Prof. Dr. A. Tsiftsoglou).
The results were announced at the IADR-CED Congress 2009, Munich, Germany and were awarded
the first Senior Robert Frank Award-Basic research.
Research Protocols
1. “Genotoxic and cytotoxic effects of different types of dental cements on normal cultured human
lymphocytes”.
2. “Genotoxic, cytostatic, apoptotic and antineoplastic effects of newly synthesized modified steroidal
esters”.
Time period: 2007-2009
These were conducted in collaboration with Department of Cell Biology and Genetics, Medical
School, Aristotle University of Thessaloniki (Head: Prof D. Mourelatos).
Research Protocols:
1. “Effects of dental restorative materials on the odontogenic differentiation potential of dental pulp
stem cells”
2. «Investigation of the multilineage differentiation potential of dental stem cells under the influence
of different microenvironmental factors»
3. “Investigation of the effects of Silicatein and silica compounds on the differentiation and
mineralization potential of dental pulp stem cells”
4. “Effects of dental restorative materials on key signaling pathways (Notch and Wnt/beta catenin)
regulating dental pulp stem cell fate”.
Time period: 2009-today
These were conducted in collaboration with the Department of Conservative Dentistry,
Periodontology and Preventive Dentistry, Medical University of Hannover -MHH (Director:
Prof. Dr. W. Geurtsen).
Analytically, with respect to this research collaboration:
 I conducted post-doctoral research during a 6-month scientific residency at MHH (05/2009-
11/2009). For this period, I received a Scholarship from the German Academic Exchange Service
(Deutscher Akademischer Austausch Dienst-DAAD) (see Scholarships pp. 21) (Research Protocols 1
and 2)
 This research collaboration continued with subsequent scientific residencies as a Research Fellow
at the MHH (2009-2011) in the context of a Research Grant (BMBF-BIOTECmarin project) funded
by BMBF (Bundes Ministerium für Bildung und Forschung-German Ministry of Education and
Science) in cooperation with the ERC Advanced Investigator Grant Research Group at Institut of
Physiological Chemistry, University Medical Center of the Johaness Gutenberg University of Mainz,
Germany (Research Protocol 3)
 A new research protocol was conducted over the period 7/2012-10/2012, again supported by a
Scholarship from German Academic Exchange Service-Deutscher Akademischer Austausch Dienst-
DAAD) (see Scholarships pp. 21) (Research Protocol 4)
 In addition, a highly specialized training in advanced molecular biology techniques was undertaken
during another scientific visit to the MHH through the LLP/ERASMUS program of Academic
Exchanges (time period: 20-24/2/2012)
In addition, the following Research Projects supported by Research Grants are currently ongoing
or in the completion phase:
1. Research Project of 1 year duration, entitled “Investigation of the effects of growth/
morphogenetic factors and the extracellular microenvironment on the potential of dental mesenchymal
stem cells to regenerate hard and soft dental tissues’, granted by the AUTH Research Committee
(ELKE, Project Nr. 89369, Scientific Management: Dr. A. Bakopoulou). This was conducted in
collaboration with the Department of Conservative Dentistry, Periodontology and Preventive
Dentistry, Medical University of Hannover -MHH (Director: Prof. Dr. W. Geurtsen) (completed, 31-1-
2014).
2. Research Project of 1 year duration, entitled “Transplantation of autologous bone marrow
mesenchymal stem cells in the regenerative treatment of interdental intrabony periodontal defects; a
randomised controlled clinical trial”, granted by a Sponsorship by Procter & Gamble (T.
Koulouridis Grand), in collaboration with the Dep. Of Preventive Dentistry and periodontology
(Lecturer, Dr. D. Apitzidou) (ELKE, Project Nr. 90467, Scientific Management: Dr. A.
Bakopoulou) (ongoing)
3. Research Project of 2 years duration, entitled “Multipotent mesenchymal stem cells of dental
origin. Potential application in neoangiogenesis of tissues and organs in the context of Regenerative
Medicine/Dentistry”, granted by the “Alexander S. Onassis” Public benefit Foundation (Scientific
Management: Dr. A. Bakopoulou). This Research Protocol is currently running in collaboration with
the Department of Conservative Dentistry, Periodontology and Preventive Dentistry, Medical
University of Hannover -MHH (Director: Prof. Dr. W. Geurtsen) and the Department of
Pharmacology, School of Pharmaceutical Sciences, Aristotle University of Thessaloniki (Head: Prof.
Dr. A. Tsiftsoglou)
4. Research Project of 18 months duration, entitled “Dental Tissue Engineering using novel
biomimetic scaffold materials in combination with stem cells of dental origin and low energy level
irradiation” granted by NSRF 2007-2013, European Social Fund, Operational Programme for
Education and Lifelong Learning, ARISTEIA II (Proposal Acronym: DentBioTisEng) (Scientific
Management: Prof. P. Koidis). I am a member of the Main Research Team (initiated 10 Feb 2014,
ongoing until 07/15) (with the participation of Prof. Dr. Geurtsen, as an external member of the
research team)

Επιλεγμένες δημοσιεύσεις σε Διεθνή Περιοδικά:  

1. Bakopoulou A, Kritis A, Andreadis D, Papachristou E, Leyhausen G, Koidis P, Geurtsen W,
Tsiftsoglou A. Angiogenic potential and secretome of human apical papilla mesenchymal stem cells in
various stress microenvironments Stem Cells and Development 2015 (in press)
2. Bakopoulou A, Leyhausen G, Volk J, Papachristou E, Koidis P, Geurtsen W. Wnt/β-catenin
signaling regulates Dental Pulp Stem Cells’ responses to pulp injury by resinous monomers. Dent
Mater. 2015;31(5):542-55.
3. Bakopoulou A, Leyhausen G, Volk J, Koidis P, Geurtsen W. Comparative characterization of
STRO-1(neg)/CD146(pos) and STRO-1(pos)/CD146(pos) apical papilla stem cells enriched with flow
cytometry. Arch Oral Biol. 2013;58(10):1556-68.
4. Bakopoulou A, Leyhausen G, Volk J, Tsiftsoglou A, Garefis P, Koidis P, Geurtsen W.
Comparative analysis of in vitro osteo/odontogenic differentiation potential of human dental pulp stem
cells (DPSCs) and stem cells from the apical papilla (SCAP). Arch Oral Biol. 2011;56(7):709-21.
5. Bakopoulou A, Leyhausen G, Volk J, Tsiftsoglou A, Garefis P, Koidis P, Geurtsen W. Assessment
of the impact of two different isolation methods on the osteo/odontogenic differentiation potential of
human dental stem cells derived from deciduous teeth. Calcif Tissue Int. 2011;88(2):130-41.
6. Paschalidis T, Bakopoulou A, Papa P, Leyhausen G, Geurtsen W, Koidis P. Dental pulp stem cells’
secretome enhances pulp repair processes and compensates TEGDMA-induced cytotoxicity. Dent
Mater. 2014;30(12):e405-18.
7. Andreadis D, Bakopoulou A, Leyhausen G, Epivatianos A, Volk J, Markopoulos A, Geurtsen W.
Minor salivary glands of the lips: a novel, easily accessible source of potential stem/progenitor cells.
Clin Oral Investig. 2014;18(3):847-56.
8. Bakopoulou A, Leyhausen G, Volk J, Koidis P, Geurtsen W. Effects of resinous monomers on the
odontogenic differentiation and mineralization potential of highly proliferative and clonogenic
cultured apical papilla stem cells. Dent Mater. 2012;28(3):327-39.
9. Bakopoulou A, Leyhausen G, Volk J, Tsiftsoglou A, Garefis P, Koidis P, Geurtsen W. Effects of
HEMA and TEDGMA on the in vitro odontogenic differentiation potential of human pulp
stem/progenitor cells derived from deciduous teeth. Dent Mater. 2011;27(6):608-17.
10. Bakopoulou A, Papadopoulos T, Garefis P. Molecular toxicology of substances released from
resin-based dental restorative materials. Int J Mol Sci. 2009 ;10(9):3861-99
11. Kontonasaki E, Bakopoulou A, Theocharidou A, Theodorou G, Papadopoulou L, Kantiranis N,
Bousnaki M, Chatzichristou C, Papachristou E, Paraskevopoulos KM, Koidis P. Effective cell growth
potential of Mg-based bioceramic scaffolds towards targeted dentin regeneration. Balkan Journal of
Dental Medicine 2015 (in press)
12. Malliari M, Bakopoulou A, Koidis P. First diagnosis of rheumatoid arthritis in a patient with
temporomandibular disorder: a case report. Int J Prosthodont. 2015 Mar-Apr;28(2):124-6
13. Bakopoulou A, Mourelatos D, Tsiftsoglou AS, Giassin NP, Mioglou E, Garefis P. Genotoxic and
cytotoxic effects of different types of dental cement on normal cultured human lymphocytes. Mutat
Res. 2009;672(2):103-12.
14. Bakopoulou A, Mourelatos D, Tsiftsoglou AS, Mioglou E, Garefis P. Sister-chromatid exchange,
chromosomal aberrations and delays in cell-cycle kinetics in human lymphocytes induced by dental
composite resin eluates. Mutat Res. 2008;649(1-2):79-90.
15. Bakopoulou A, Tsiftsoglou A, Galaktidou G, Markala D, Triviai I, Garefis P. Patterns of cell death
and cell cycle profiles of cultured WEHI 13 var fibroblasts exposed to eluates of composite resins used
for direct and indirect restorations. Eur J Oral Sci. 2007;115(5):397-407.

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Pub Med:  http://www.ncbi.nlm.nih.gov/pubmed/?term=Bakopoulou+A